Basic Information
VIS ID
TVIS44017575
Fusion event
HTLV-1-ATP8A2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr13
Cytoband
q12.13
Reference genome
GRCh37/hg19
Start
26486232/25912094 (Hg38)
End
26486232/25912094 (Hg38)
Orient
+
Location type
Intronic
Target gene
ATP8A2
miRNAs that regulate target gene
hsa-mir-30a-5p ; hsa-mir-16-5p ; hsa-mir-675-5p ; hsa-mir-1271-5p ; hsa-mir-182-5p ; hsa-mir-196a-3p ; hsa-mir-2278 ; hsa-mir-29b-1-5p ; hsa-mir-3919 ; hsa-mir-3925-5p ; hsa-mir-4468 ; hsa-mir-5087 ; hsa-mir-6501-3p ; hsa-mir-96-5p ; hsa-mir-129-5p
Nearest miRNA
hsa-mir-2276/Upstream/1749590; hsa-mir-1267/Downstream/13751940;
Nearest TSS
ENST00000623511/Upstream/344961; ENST00000621997/Downstream/138937;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/442746, chr13-CpG: 49/Downstream/100055
Upstream sequence
atccaacaatcccacttctgggcatttacccaaagatttcaaatcagtatgtcaaaaagatgtttacactcccaaattaattgcaacactattcacaata
Downstream sequence
gcagagttatggaatcaacctaagtgtcaatcaatggatgaatggataaagaaaatgtgagacacacacacacacacacacacacacacacacacacaca
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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