Basic Information
VIS ID
TVIS44017576
Fusion event
HTLV-1-CDK8 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr13
Cytoband
q12.13
Reference genome
GRCh37/hg19
Start
26878566/26304429 (Hg38)
End
26878566/26304429 (Hg38)
Orient
+
Location type
Intronic
Target gene
CDK8
miRNAs that regulate target gene
hsa-mir-26a-5p ; hsa-mir-193b-3p ; hsa-mir-10a-5p ; hsa-mir-107 ; hsa-mir-195-5p ; hsa-mir-101-3p
Nearest miRNA
hsa-mir-2276/Upstream/2141925; hsa-mir-1267/Downstream/13359605;
Nearest TSS
ENST00000623511/Upstream/50290; ENST00000465820/Downstream/80782;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/49463, chr13-CpG: 160/Downstream/253002
Nearest cancer related gene
CDK8(OG, No orient, 0)
Upstream sequence
TTTAAAAATCAAGCCTAACAAACATTATATTTATTTTACCTAGTATTTCATTTAAATCTTTCAtgctttctatttatctctccagctttatgttttgtct
Downstream sequence
tctactttttatattattgtgtattattctatcttcctcctcctattaacttggatgctttatattcttgctactcctttagtggtttttctagagatta
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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