Basic Information
VIS ID
TVIS44017587
Fusion event
HTLV-1-PDS5B integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr13
Cytoband
q13.1
Reference genome
GRCh37/hg19
Start
33345170/32771032 (Hg38)
End
33345170/32771032 (Hg38)
Orient
-
Location type
Intronic
Target gene
PDS5B
miRNAs that regulate target gene
hsa-mir-27a-3p ; hsa-mir-92a-3p
Nearest miRNA
hsa-mir-2276/Upstream/8608528; hsa-mir-1267/Downstream/6893002;
Nearest TSS
ENST00000623511/Upstream/842; ENST00000617901/Downstream/11842;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/183334, chr13-CpG: 157/Downstream/244758
Nearest cancer related gene
PDS5B(TSG, No orient, 0)
Upstream sequence
CTTGTACATTTTTACAGGTGCAGGCAAATCTTCATAAATGAATACCAAATAGTATATTATTTCCTATACAGACTTTATGATATCTAAAGAAATCATAAGG
Downstream sequence
TATTTTTAAATAATCACCACACATTGACCAGGTTGCCTTGTCATTCCACACTACAATTTTTTTTTTAAATGTTTCTCATTAGCACCTTTTCCTTTAAAAA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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