Basic Information
VIS ID
TVIS44017592
Fusion event
HTLV-1-DCLK1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr13
Cytoband
q13.3
Reference genome
GRCh37/hg19
Start
36575472/36001335 (Hg38)
End
36575472/36001335 (Hg38)
Orient
+
Location type
Intronic
Target gene
DCLK1
miRNAs that regulate target gene
hsa-mir-137
Nearest miRNA
hsa-mir-2276/Upstream/11838831; hsa-mir-1267/Downstream/3662699;
Nearest TSS
ENST00000623511/Upstream/145474; ENST00000379848/Downstream/129971;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/522353, chr13-CpG: 75/Downstream/129568
Upstream sequence
ccgcgcctggccGCATAACTGATTCTTTAGGAGCAGTAACAAAACACAAGGTTGAAAGAAACATCCAACAGCAAAAAACAATGCTACCTTTTTGAACAGA
Downstream sequence
CAATAATTCTTTCAGCAACATCAAAGTAATAAAGTTTAATGGAAAgaaccagctgcctatgggttccagaagtctcctggtttgtgtgacctcatgcagg
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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