Basic Information
VIS ID
TVIS44017595
Fusion event
HTLV-1-EXOSC8 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr13
Cytoband
q13.3
Reference genome
GRCh37/hg19
Start
37576212/37002075 (Hg38)
End
37576212/37002075 (Hg38)
Orient
+
Location type
Intronic
Target gene
EXOSC8
miRNAs that regulate target gene
hsa-mir-24-3p
Nearest miRNA
hsa-mir-2276/Upstream/12839571; hsa-mir-1267/Downstream/2661959;
Nearest TSS
ENST00000623511/Upstream/601; ENST00000470423/Downstream/193;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/989, chr13-CpG: 52/Downstream/57183
Upstream sequence
CACTCTGAATCCTTGTTTCAGAGCAAGAACGACATGATTCTTTTGACACAGATTGAGCTTTTAAAGAGCTCACTCAAAGGGCTTTTAGACGCCAATCTTC
Downstream sequence
TAATCGTTTATGGCAGAGTTAAGGACAGCAATTGAATGTGATTGCTACTACAAGGATTTTTACTTTCTAGAATTACTTTTAGTTAAAAAGTTGTGGAGAT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
Curate