Basic Information
VIS ID
TVIS44017609
Fusion event
HTLV-1-KPNA3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr13
Cytoband
q14.2
Reference genome
GRCh37/hg19
Start
50315925/49741789 (Hg38)
End
50315925/49741789 (Hg38)
Orient
-
Location type
Intronic
Target gene
KPNA3
miRNAs that regulate target gene
hsa-mir-16-5p ; hsa-mir-92a-3p ; hsa-mir-219a-1-3p ; hsa-mir-1199-5p ; hsa-mir-6751-3p ; hsa-mir-4303 ; hsa-mir-3200-5p ; hsa-mir-548c-3p ; hsa-mir-455-5p ; hsa-mir-599 ; hsa-mir-374a-3p ; hsa-mir-487b-5p ; hsa-mir-487a-5p ; hsa-mir-4524b-5p ; hsa-mir-4524a-5p ; hsa-mir-524-5p ; hsa-mir-520d-5p ; hsa-mir-1279 ; hsa-mir-409-5p ; hsa-mir-487a-3p ; hsa-mir-154-3p ; hsa-mir-208b-5p ; hsa-mir-208a-5p ; hsa-mir-646 ; hsa-mir-15a-5p ; hsa-mir-15b-5p ; hsa-mir-424-5p ; hsa-mir-497-5p ; hsa-mir-195-5p ; hsa-mir-6838-5p ; hsa-mir-503-5p ; hsa-mir-1244 ; hsa-mir-676-5p
Nearest miRNA
hsa-mir-2276/Upstream/5545589; hsa-mir-1267/Downstream/254626;
Nearest TSS
ENST00000623511/Upstream/36037; ENST00000615830/Downstream/51097;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/50069, chr13-CpG: 124/Downstream/50135
Upstream sequence
gtgatccgcccgcctcggcctcccaaagtgctgggattataggcgtgagccaccgtgcccaatccttgcccattttttaattgttagttttcttgctatt
Downstream sequence
gagttcattatatataaccccttatcagatgtatggtttgcaaatattttctataggttctctctttattaatagtctcttttgctgtgcagaacctttt
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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