Basic Information
VIS ID
TVIS44017640
Fusion event
HTLV-1-TBC1D4 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr13
Cytoband
q22.2
Reference genome
GRCh37/hg19
Start
76001254/75427118 (Hg38)
End
76001254/75427118 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA13E
Target gene
TBC1D4
miRNAs that regulate target gene
hsa-mir-98-5p ; hsa-mir-30a-5p ; hsa-mir-19b-3p ; hsa-mir-29b-2-5p ; hsa-mir-7150 ; hsa-mir-4736 ; hsa-mir-4763-3p ; hsa-mir-1207-5p ; hsa-mir-1193 ; hsa-mir-6722-3p ; hsa-mir-1909-3p ; hsa-mir-8069 ; hsa-mir-4456 ; hsa-mir-4494 ; hsa-mir-4463
Nearest miRNA
hsa-mir-1297/Upstream/9208794; hsa-mir-1267/Downstream/2270894;
Nearest TSS
ENST00000623511/Upstream/49824; ENST00000471792/Downstream/54996;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/1291437, chr13-CpG: 197/Downstream/53598
Upstream sequence
agcctgggcgacaagagactgtctcagaagaaaaagaaaacaaaaaaGGAATGAATACCTTCAAAATATAAACAttttttttttttttgagacggagtct
Downstream sequence
cactctgtctcccaggctggagtgcagtggcgcgatctcgctcactgcaagctccgcctcccaggttcacaccattctcctgcctcagcctcccgagtag
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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