Basic Information
VIS ID
TVIS44017663
Fusion event
HTLV-1-MEG3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr14
Cytoband
q32.2
Reference genome
GRCh37/hg19
Start
101307419/100841082 (Hg38)
End
101307419/100841082 (Hg38)
Orient
+
Location type
ncRNA_intronic
Target gene
MEG3
miRNAs that regulate target gene
hsa-mir-181a-5p ; hsa-mir-181b-5p ; hsa-mir-181d-5p ; hsa-mir-140-5p ; hsa-mir-133a-3p ; hsa-mir-770-5p ; hsa-mir-125a-5p ; hsa-mir-664a-3p
Nearest miRNA
hsa-mir-1260a/Upstream/26508; hsa-mir-1185-1/Downstream/11308;
Nearest TSS
ENST00000550708/Upstream/4813; ENST00000398460/Downstream/16163;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/12795, chr14-CpG: 23/Downstream/40966
Nearest cancer related gene
MEG3(TSG, No orient, 0)
Upstream sequence
GTTGGCGGTAGGGGGCTCAGAAATCCACAGGGCTGTTGTTTCACAGTTAGCCAGGAGAGGAGGGGGTCATGGTGGCCCGCAGGGATGGTGGGCAGCTGCG
Downstream sequence
AGAGAGGGGACGCTTCAGGTTAGAGCGAAGCTGTTTGCACCACCACTGCCCCAGACTGCCGTAAGGGTAGGGCCACTCCAGAGGCACCAGGGACAAAGTC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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