Basic Information
VIS ID
TVIS44017665
Fusion event
HTLV-1-PPP2R5C integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr14
Cytoband
q32.31
Reference genome
GRCh37/hg19
Start
102313085/101846748 (Hg38)
End
102313085/101846748 (Hg38)
Orient
-
Location type
Intronic
Target gene
PPP2R5C
miRNAs that regulate target gene
hsa-mir-16-5p ; hsa-mir-30a-5p ; hsa-mir-31-3p ; hsa-mir-135b-5p ; hsa-mir-15a-5p ; hsa-mir-103a-3p ; hsa-mir-107 ; hsa-mir-15b-5p ; hsa-mir-195-5p ; hsa-mir-424-5p ; hsa-mir-497-5p ; hsa-mir-1277-5p ; hsa-mir-3190-3p ; hsa-mir-3607-5p ; hsa-mir-3611 ; hsa-mir-4524a-5p ; hsa-mir-5011-5p ; hsa-mir-4524b-5p ; hsa-mir-6505-5p ; hsa-mir-6833-5p ; hsa-mir-6838-5p ; hsa-mir-7114-5p ; hsa-mir-29c-5p ; hsa-mir-4680-5p ; hsa-mir-134-3p ; hsa-mir-646 ; hsa-mir-503-5p ; hsa-mir-3664-5p ; hsa-mir-548ao-3p ; hsa-mir-193b-3p ; hsa-mir-193a-3p
Nearest miRNA
hsa-mir-1185-1/Upstream/286326; hsa-mir-12121/Downstream/692896;
Nearest TSS
ENST00000550708/Upstream/7217; ENST00000556570/Downstream/32474;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/64806, chr14-CpG: 17/Downstream/44802
Nearest cancer related gene
PPP2R5C(TSG, No orient, 0)
Upstream sequence
AGTAAGAGATCCTTGTTACCAAAAATGAGGGCTGGCAGGCCTGTACCGGGGAAGGCAGAGCTTGTGTGTCGGGTTTGCCTGGAAGAGGGCTGAGGGCTGG
Downstream sequence
GTTCATGGGCTGTAGCTAAGGGCCTTCTCTTCTGAAGGAGAACTGCCTACCTCTGGCTTCTTGGTTTCAGTTCACCCATGTCTCTCCTGAACAGAGATCA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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