Basic Information
VIS ID
TVIS44017668
Fusion event
HTLV-1-TMEM179 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr14
Cytoband
q32.33
Reference genome
GRCh37/hg19
Start
105058484/104592147 (Hg38)
End
105058484/104592147 (Hg38)
Orient
+
Location type
UTR3
Target gene
TMEM179
miRNAs that regulate target gene
hsa-mir-6845-5p ; hsa-mir-6762-5p ; hsa-mir-6784-5p ; hsa-mir-4655-5p ; hsa-mir-7109-3p
Nearest miRNA
hsa-mir-1185-1/Upstream/474633; hsa-mir-12121/Downstream/85547;
Nearest TSS
ENST00000550708/Upstream/2300; ENST00000540171/Downstream/362;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/3371, chr14-CpG: 90/Downstream/12034
Upstream sequence
GGGAAGGCAGCTCCCTCCTCTCTCAGGTGGATGCTGGGCGTGGGAGCCCATGGGAGGGGCAGAGGGGCTGTCCACACAGCACCCACGGCTCCCATcacgc
Downstream sequence
acacaatgctcacacgcacaggcgtgcacatgctcacatgcaacacacgcacattcacatgcacttacgcacatgctgcacacactgcagacacacctgc
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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