Basic Information
VIS ID
TVIS44017670
Fusion event
HTLV-1-PLD4 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr14
Cytoband
q32.33
Reference genome
GRCh37/hg19
Start
105395814/104929477 (Hg38)
End
105395814/104929477 (Hg38)
Orient
-
Location type
Intronic
Target gene
PLD4
miRNAs that regulate target gene
hsa-mir-335-5p
Nearest miRNA
hsa-mir-1185-1/Upstream/64066; hsa-mir-4507/Downstream/221301;
Nearest TSS
ENST00000550708/Upstream/4597; ENST00000472702/Downstream/1144;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/22484, chr14-CpG: 209/Downstream/2262
Upstream sequence
CCCGACACTGGCCAGGACATCCACCGACCTGCAGGTTCTGGCTGCCCGAGGTGGGTACCTGCACCATGCTGGGCACCACTGCCCTAGCGTCGGGCATGGG
Downstream sequence
CTGTCTGGCTGGCACCACAGGACAAGGAAAAGAAGTGAGGGTGGGAAAGGTGCCCTGGACTTCCCTAGGACACCCCAGGAGGGCAGGACCCAGGGCTCTG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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