Basic Information
VIS ID
TVIS44017672
Fusion event
HTLV-1-BRF1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr14
Cytoband
q32.33
Reference genome
GRCh37/hg19
Start
105757571/105291234 (Hg38)
End
105757571/105291234 (Hg38)
Orient
+
Location type
Intronic
Target gene
BRF1
miRNAs that regulate target gene
hsa-mir-877-3p ; hsa-mir-92a-3p
Nearest miRNA
hsa-mir-1185-1/Upstream/140370; hsa-mir-4507/Downstream/329882;
Nearest TSS
ENST00000550708/Upstream/41830; ENST00000548265/Downstream/9234;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/18907, chr14-CpG: 188/Downstream/8987
Nearest cancer related gene
BRF1(TSG, No orient, 0)
Upstream sequence
GCCAAGACTGCCCCCCTGTGTACAGCAAGGGAGGACCTGCGGTTCCACCAGAGCCAGAGCAGGGCCAGAGGCCGCAGGGGCACCTCTGAGCTCCGACAAA
Downstream sequence
GCCAGCAACACCCCATACCGCCGAACAGACAGAAAGGCGGGCCAGGGGCCCTCCATGTCCTGAAAGACCCAGCACAGCACTGTCCATTTCACACCAGGAT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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