Basic Information
VIS ID
TVIS44017676
Fusion event
HTLV-1-TEP1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr14
Cytoband
q11.2
Reference genome
GRCh37/hg19
Start
20851208/20383049 (Hg38)
End
20851208/20383049 (Hg38)
Orient
-
Location type
Intronic
Target gene
TEP1
miRNAs that regulate target gene
hsa-mir-484 ; hsa-mir-16-5p ; hsa-mir-1231 ; hsa-mir-4288 ; hsa-mir-632 ; hsa-mir-6805-3p ; hsa-mir-6888-3p ; hsa-mir-5691 ; hsa-mir-4713-5p ; hsa-mir-3194-3p ; hsa-mir-1301-5p ; hsa-mir-6502-5p ; hsa-mir-3120-5p ; hsa-mir-4766-5p ; hsa-mir-2116-3p ; hsa-mir-146a-3p ; hsa-mir-532-3p ; hsa-mir-150-5p ; hsa-mir-5698 ; hsa-mir-744-3p ; hsa-mir-4423-5p ; hsa-mir-6501-5p ; hsa-mir-143-5p ; hsa-mir-4284 ; hsa-mir-122-5p ; hsa-mir-504-3p ; hsa-mir-3135b ; hsa-mir-6499-3p ; hsa-mir-367-5p ; hsa-mir-1267 ; hsa-mir-4638-5p ; hsa-mir-1307-3p ; hsa-mir-6741-3p ; hsa-mir-6812-3p ; hsa-mir-4430 ; hsa-mir-3652
Nearest miRNA
hsa-mir-1185-1/Downstream/640265;
Nearest TSS
ENST00000550708/Upstream/787; ENST00000555435/Downstream/8696;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/694797, chr14-CpG: 22/Downstream/30361
Upstream sequence
TCCCCTCACCCCGAGAGGCCCTGGAAAGGCCATTCACCGGGGGAAGAGGGCTGGGTGACATGATCAGGAATCACAATTTTCTTATTAACAACTTCCCATG
Downstream sequence
GACAGAATTTCTGAGAAAACAAAGGAGCAGGTCTGTGCAAGGCAGCTAGCGGCCTCGGCACCCCAGGTCCTCATAGCTCCCAGATTCACCCCACACACCC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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