Basic Information
VIS ID
TVIS44017695
Fusion event
HTLV-1-TTC6 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr14
Cytoband
q21.1
Reference genome
GRCh37/hg19
Start
38073466/37604261 (Hg38)
End
38073466/37604261 (Hg38)
Orient
+
Location type
Intronic
Target gene
TTC6
miRNAs that regulate target gene
hsa-mir-335-5p
Nearest miRNA
hsa-mir-208a/Upstream/651870; hsa-mir-1185-1/Downstream/10156734;
Nearest TSS
ENST00000550708/Upstream/8202; ENST00000554555/Downstream/6990;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/4259, chr14-CpG: 39/Downstream/6773
Upstream sequence
AGGGAGCTCTCCCATGGGAACTGGGCTGCCGGGGGGCGGAGTCTCAGTGTCCACCAGGACCCTGCCTGGAATTTCCTAATTTCCTTGACTGGTGGAGCTA
Downstream sequence
CTCTCCACCCAGTCAGTGATGGATGACAAAAGAAAAGCACCATCCGAAGGAGATCCAGAGACTGCATCAAGTTCACATTAAGGACCTTCTGGGGTAAGGT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
Curate