Basic Information
VIS ID
TVIS44017719
Fusion event
HTLV-1-SLC35F4 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr14
Cytoband
q23.1
Reference genome
GRCh37/hg19
Start
58151594/57684876 (Hg38)
End
58151594/57684876 (Hg38)
Orient
+
Location type
Intronic
Target gene
SLC35F4
miRNAs that regulate target gene
hsa-mir-128-3p
Nearest miRNA
hsa-mir-208a/Upstream/2806683; hsa-mir-1185-1/Downstream/1962086;
Nearest TSS
ENST00000550708/Upstream/87979; ENST00000556243/Downstream/114631;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/293243, chr14-CpG: 124/Downstream/180082
Upstream sequence
ttgaagagtgattttccaggcatcccctcatctcacttggttCTGATGAAAACAATGTTCCTTTTGTCCTCTCTCTCAGGAGTTTCCCCAGAGGGATAGC
Downstream sequence
GTTGGTAGGTAGATTGTGTAGCTCCTTAGTTAGCTGCCTGGGAGGGTTTAGCTCCAGTCATGGGCAGCTTACAGGATAATTAGCCCTTTTTGTTTTGAGC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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