Proximate region of VIS (GRCh38)VISEnhancerEnhancer/PromoterPromoterGene63423442632041146329321963312835633188796329491863296937632981266329954763273543632744376326620363266432632744436327463263313778
Basic Information
VIS ID
TVIS44017730
Fusion event
HTLV-1-GPHB5 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr14
Cytoband
q23.2
Reference genome
GRCh37/hg19
Start
63780491/63313778 (Hg38)
End
63780491/63313778 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA14B
Target gene
GPHB5
miRNAs that regulate target gene
hsa-mir-148b-3p ; hsa-mir-122-5p
Nearest miRNA
hsa-mir-208a/Upstream/2665067; hsa-mir-1185-1/Downstream/781246;
Nearest TSS
ENST00000550708/Upstream/14231; ENST00000561909/Downstream/4071;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/267500, chr14-CpG: 103/Downstream/229049
Upstream sequence
cccagctcagggcctttgcacttactgttccttctgcctggaacattcttctcccgtatgattcactctttcaccaaccttgggtttttgttagaatgtc
Downstream sequence
accctctcagggaagcatttcctgaccatcctatttaaaattgcaacattccatctccatgcccagaaacttcccatcccccatcttgctttattttcca
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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