Proximate region of VIS (GRCh38)VISEnhancerEnhancer/PromoterPromoterGene8863265688465778885547338838492488470350884993348851550288487168884899908848127188483601884677638847003988470490884720678847328588474521884922778849324688508790
Basic Information
VIS ID
TVIS44017754
Fusion event
HTLV-1-PTPN21 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr14
Cytoband
q31.3
Reference genome
GRCh37/hg19
Start
88975134/88508790 (Hg38)
End
88975134/88508790 (Hg38)
Orient
+
Location type
Intronic
Target gene
PTPN21
miRNAs that regulate target gene
hsa-mir-615-3p
Nearest miRNA
hsa-mir-1260a/Upstream/11242500; hsa-mir-1185-1/Downstream/5439436;
Nearest TSS
ENST00000550708/Upstream/9456; ENST00000556328/Downstream/41740;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/28597, chr14-CpG: 29/Downstream/42526
Upstream sequence
TATAAGAGTTTGCTTACCTTGTTTGGTAGAAGTTCCCTAGCACTGGAAAGTAAAGCCAGAGAAAAATGGTTTCTGATATTTCAGACCAGGCTGATATTAA
Downstream sequence
AATGTTTCTGATGAAATCCCTCAAAACAGCTGTTAAGATGCTTTCTTAATATCTGGTAATGTGGGTTTACTTCTGTTTACCACCCTGTTTGTACTTTCAA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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