Proximate region of VIS (GRCh38)VISEnhancerEnhancer/PromoterPromoterGene886575418856290988627596885622058856455488557401885576008855995788560106885943718859443088607471
Basic Information
VIS ID
TVIS44017755
Fusion event
HTLV-1-ZC3H14 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr14
Cytoband
q31.3
Reference genome
GRCh37/hg19
Start
89073815/88607471 (Hg38)
End
89073815/88607471 (Hg38)
Orient
+
Location type
Intronic
Target gene
ZC3H14
miRNAs that regulate target gene
hsa-mir-769-5p ; hsa-mir-374b-3p ; hsa-mir-4524b-5p ; hsa-mir-4524a-5p ; hsa-mir-4519 ; hsa-mir-4274
Nearest miRNA
hsa-mir-1260a/Upstream/11341181; hsa-mir-1185-1/Downstream/5340755;
Nearest TSS
ENST00000550708/Upstream/187; ENST00000555851/Downstream/641;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/43877, chr14-CpG: 136/Downstream/184581
Upstream sequence
CATCCCCCCATCTCACCCTGCAAGTGAGTACCATCCCCCCATCTCACCCTGCAAGTACCATCCCCCATCTCACCTGGCAAGTACCATCCCATCTCACCCA
Downstream sequence
GCAAGTACCATCCCCCACATCTCAACCCTCAAGTGAGTACCATCCCATCTCACCCTGCAAGTACCATCCCATTTCACCCTGCAAGTACCATCCCCCATCT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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