Basic Information
VIS ID
TVIS44017761
Fusion event
HTLV-1-TDP1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr14
Cytoband
q32.11
Reference genome
GRCh37/hg19
Start
90496653/90030309 (Hg38)
End
90496653/90030309 (Hg38)
Orient
-
Location type
Intronic
Target gene
TDP1
miRNAs that regulate target gene
hsa-mir-1-3p ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-193b-3p ; hsa-mir-320a
Nearest miRNA
hsa-mir-1260a/Upstream/12764019; hsa-mir-1185-1/Downstream/3917917;
Nearest TSS
ENST00000550708/Upstream/45150; ENST00000282146/Downstream/31456;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/74060, chr14-CpG: 240/Downstream/30043
Upstream sequence
TTCCCTGTCCCCCTCCTCTGTGTCTTCCCTGTCACCCTCCTCTGTGTCAGTGCCCTCGCCCTCCCGGGATGTGCCTGCTCTgtgctttgctgaccctgcc
Downstream sequence
tttgattatgctgttctcacgcttggtattcttccctatcatctctctgtttattaaaattacaccaatttttcaagccctagctaaaatatcctctaca
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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