Basic Information
VIS ID
TVIS44017774
Fusion event
HTLV-1-EVL integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr14
Cytoband
q32.2
Reference genome
GRCh37/hg19
Start
100454125/99987788 (Hg38)
End
100454125/99987788 (Hg38)
Orient
-
Location type
Intronic
Target gene
EVL
miRNAs that regulate target gene
hsa-mir-221-3p
Nearest miRNA
hsa-mir-1260a/Upstream/4849802; hsa-mir-1185-1/Downstream/121631;
Nearest TSS
ENST00000550708/Upstream/9690; ENST00000557023/Downstream/31594;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/15262, chr14-CpG: 21/Downstream/156281
Nearby gene
EML1(+45730) ;
Upstream sequence
cttgtttgcccctcctagcatgtgaggatgcagcaagaaggctctatgaggaaaaggccttcatcagataggtaatttgccagtgccttcatcttggact
Downstream sequence
tctcagcttctagaactgtgagaaataaatattgtttataagccacccagtttctggtatttttgttatagcagcttgaatagactaagacatctcaaca
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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