Basic Information
VIS ID
TVIS44017786
Fusion event
HTLV-1-APBA2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr15
Cytoband
q13.1
Reference genome
GRCh37/hg19
Start
29374342/29082139 (Hg38)
End
29374342/29082139 (Hg38)
Orient
-
Location type
Intronic
Target gene
APBA2
miRNAs that regulate target gene
hsa-mir-148b-3p ; hsa-mir-615-3p
Nearest miRNA
hsa-mir-1268a/Upstream/591294; hsa-mir-10393/Downstream/1982893;
Nearest TSS
ENST00000557528/Upstream/11481; ENST00000536835/Downstream/114548;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/195077, chr15-CpG: 62/Downstream/21299
Upstream sequence
actgcatgaccggctgtttgatataagctccaggccgatgggtgcaaagaggtgtcttgttgatttcacgtgtctttcataataagtgaagccaaacact
Downstream sequence
atttcgtatgttcataggtggtttttcttttcagtgcactgccagtttgtttcctgtgctcattcctctgttagattttcacccccagctttattggcgt
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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