Basic Information
VIS ID
TVIS44017817
Fusion event
HTLV-1-TCF12 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr15
Cytoband
q21.3
Reference genome
GRCh37/hg19
Start
57295799/57003601 (Hg38)
End
57295799/57003601 (Hg38)
Orient
+
Location type
Intronic
Target gene
TCF12
miRNAs that regulate target gene
hsa-mir-204-5p ; hsa-mir-211-5p ; hsa-mir-375 ; hsa-mir-155-5p ; hsa-mir-26b-5p ; hsa-mir-1224-3p ; hsa-mir-548v ; hsa-mir-33a-3p ; hsa-mir-139-5p ; hsa-mir-8485
Nearest miRNA
hsa-mir-10393/Upstream/1630567; hsa-mir-11181/Downstream/2167582;
Nearest TSS
ENST00000557528/Upstream/84084; ENST00000569880/Downstream/60147;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/83794, chr15-CpG: 58/Downstream/302739
Upstream sequence
aatgacttgggggccatgaaatagtgaaatcatcaacaaaaacacaacaatgcaaaaacgtggcacaaaataggctactgaaaggactcttgtttacatt
Downstream sequence
ataagagctgaagcaagaaagcctattcgttgtctgctgggaatgtgcatgtttggtgactcagattttttgttatcccgtgtgtgtctgcaaatgactg
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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