Basic Information
VIS ID
TVIS44017824
Fusion event
HTLV-1-TLN2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr15
Cytoband
q22.2
Reference genome
GRCh37/hg19
Start
62897989/62605790 (Hg38)
End
62897989/62605790 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA15A
Target gene
TLN2
miRNAs that regulate target gene
hsa-mir-194-5p ; hsa-mir-132-3p ; hsa-mir-4314 ; hsa-mir-6508-3p ; hsa-mir-4726-5p ; hsa-mir-4640-5p ; hsa-mir-378g ; hsa-mir-4486 ; hsa-mir-6860 ; hsa-mir-612 ; hsa-mir-5189-5p ; hsa-mir-3187-5p ; hsa-mir-1285-3p ; hsa-mir-4328 ; hsa-mir-25-5p ; hsa-mir-658 ; hsa-mir-6087 ; hsa-mir-6804-5p ; hsa-mir-6856-5p ; hsa-mir-6758-5p
Nearest miRNA
hsa-mir-10393/Upstream/262652; hsa-mir-11181/Downstream/218167;
Nearest TSS
ENST00000557528/Upstream/16110; ENST00000474847/Downstream/39391;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/213593, chr15-CpG: 21/Downstream/91925
Nearby gene
MGC15885(-31382) ;
Upstream sequence
CTTTTCTTCCTTGTGACTCGGTTGAACACCAGAGTCACCTATAAGCCCATGTCATTGGTGTATCTAAGTCACGTTGGACACCGTAGCAGCAAAGAGATCT
Downstream sequence
GGGCAATCAATATATGATGTTTAGACCTGCAGCCTCCCCAAGCTGCAAGCGAACTACCCTTCCCATCTTCACGAAATGTCTCTTCAGATGTGCCTGGTAC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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