Basic Information
VIS ID
TVIS44017880
Fusion event
HTLV-1-IL21R integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr16
Cytoband
p12.1
Reference genome
GRCh37/hg19
Start
27438286/27426965 (Hg38)
End
27438286/27426965 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA16E
Target gene
IL21R
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-148b-3p ; hsa-mir-7-5p ; hsa-mir-30a-5p ; hsa-mir-30c-5p ; hsa-mir-30d-5p ; hsa-mir-30b-5p ; hsa-mir-30e-5p ; hsa-mir-448 ; hsa-mir-3607-3p ; hsa-mir-4643 ; hsa-mir-4789-3p ; hsa-mir-5580-3p ; hsa-mir-8485 ; hsa-mir-7106-5p ; hsa-mir-4748 ; hsa-mir-5572 ; hsa-mir-4260 ; hsa-mir-450a-2-3p ; hsa-mir-6763-5p ; hsa-mir-6857-5p ; hsa-mir-3150a-3p ; hsa-mir-6810-5p ; hsa-mir-2110 ; hsa-mir-128-2-5p ; hsa-mir-128-1-5p ; hsa-mir-6825-5p ; hsa-mir-939-5p ; hsa-mir-1343-5p ; hsa-mir-3175 ; hsa-mir-6781-5p ; hsa-mir-766-5p ; hsa-mir-483-5p ; hsa-mir-6782-3p ; hsa-mir-8064 ; hsa-mir-502-3p ; hsa-mir-501-3p
Nearest miRNA
hsa-mir-1225/Upstream/1401655; hsa-mir-11401/Downstream/964017;
Nearest TSS
ENST00000527434/Upstream/24791; ENST00000561953/Downstream/279;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/112591, chr16-CpG: 56/Downstream/122723
Upstream sequence
aattcaacatgattaagcaacataggtggtttttggctcatgggaatgagaaatccacagggtggacatcagatatggctggatccaggacctcccatga
Downstream sequence
tgccatggggactcctgacctgtatttctcagtatggctgtcattttcaaggaggctgtctctaagaggtgacaaagatggctacaagctctgagaagat
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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