Basic Information
VIS ID
TVIS44017924
Fusion event
HTLV-1-CDH8 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr16
Cytoband
q21
Reference genome
GRCh37/hg19
Start
61892744/61858840 (Hg38)
End
61892744/61858840 (Hg38)
Orient
-
Location type
Intronic
Target gene
CDH8
miRNAs that regulate target gene
hsa-mir-4659b-3p ; hsa-mir-4659a-3p ; hsa-mir-6875-3p ; hsa-mir-6809-3p ; hsa-mir-6833-3p ; hsa-mir-4768-5p ; hsa-mir-6873-3p ; hsa-mir-6749-3p ; hsa-mir-6792-3p ; hsa-mir-4691-5p ; hsa-mir-211-5p ; hsa-mir-204-5p ; hsa-mir-4469 ; hsa-mir-6832-3p ; hsa-mir-6741-3p ; hsa-mir-6867-3p ; hsa-mir-6817-3p ; hsa-mir-6845-3p ; hsa-mir-7113-3p ; hsa-mir-3667-3p ; hsa-mir-4667-3p ; hsa-mir-1470 ; hsa-mir-642a-5p ; hsa-mir-2276-5p ; hsa-mir-6892-3p ; hsa-mir-4685-3p ; hsa-mir-4287 ; hsa-mir-629-3p ; hsa-mir-4713-5p ; hsa-mir-7110-3p ; hsa-mir-1304-3p ; hsa-mir-6769b-3p ; hsa-mir-4723-3p ; hsa-mir-3183
Nearest miRNA
hsa-mir-1225/Upstream/4086488; hsa-mir-11401/Downstream/5343481;
Nearest TSS
ENST00000527434/Upstream/40797; ENST00000562349/Downstream/59481;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/2103672, chr16-CpG: 117/Downstream/176377
Upstream sequence
tccatagggctctagagatggcatgcccgttgagGAAATGGGCCAAGCTTTTATATTCCAGCAGGAAACAGTTACAGCATGCAAGATGCCCCCTGAGAAC
Downstream sequence
GGAGCCTTAGTCTTGGCCCAAGCAGCTCCCTTCAGGGGAGGACAACTACAAAATGGTGGCAGGGAGTATCGGTGTTGGGCTGTCAGAAATCAACATGTTC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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