Basic Information
VIS ID
TVIS44017932
Fusion event
HTLV-1-CES4A integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr16
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
67040746/67006843 (Hg38)
End
67040746/67006843 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA16B
Target gene
CES4A
miRNAs that regulate target gene
hsa-mir-6870-3p ; hsa-mir-4673 ; hsa-mir-4645-5p ; hsa-mir-1972 ; hsa-mir-6715b-5p ; hsa-mir-4269 ; hsa-mir-1324 ; hsa-mir-4524b-3p ; hsa-mir-8066
Nearest miRNA
hsa-mir-1225/Upstream/9234491; hsa-mir-11401/Downstream/195478;
Nearest TSS
ENST00000527434/Upstream/320; ENST00000564034/Downstream/22273;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/5825, chr16-CpG: 74/Downstream/6859
Upstream sequence
GGCCTTTCCATGGGTAAGGAGAAGGCACTTAGCCTCCAGATGATGAAATACTGGGCCAACTTTGCCCGCACAGGGTGAGTCTGCCCCCCAGCACATCTGG
Downstream sequence
GCATTCTACCTGCCCAGTGCTGGACCTGAAGAAGCCAGCTGCTTCGGATATTTGCCCCAGCATGTCCTACAGGAACTGCCCAGTCGGCCCAAACAGGGTG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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