Basic Information
VIS ID
TVIS44017949
Fusion event
HTLV-1-WWOX integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr16
Cytoband
q23.1
Reference genome
GRCh37/hg19
Start
78417509/78383612 (Hg38)
End
78417509/78383612 (Hg38)
Orient
+
Location type
Intronic
Target gene
WWOX
Nearest miRNA
hsa-mir-1225/Upstream/1514593; hsa-mir-11401/Downstream/3001406;
Nearest TSS
ENST00000527434/Upstream/142394; ENST00000620008/Downstream/41259;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/283443, chr16-CpG: 44/Downstream/1205982
Nearest cancer related gene
WWOX(TSG, No orient, 0)
Upstream sequence
CCTAACAATCAGCAGTTCACCTCTCGAAAAGGGGTTCCGTTTGCAATCTGTCAGCCACTACCTTCTTATTTAGAGCATGTCCCACTACAAACATTTCTAT
Downstream sequence
AAAGTTACTAAGTTTGTTAGACAATTAGAATTGCAAACCCCCAACACACACATAAACACATATGCACACCCTAATTTAAAGGCTGCATTTTCCATCCCCT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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