Basic Information
VIS ID
TVIS44017956
Fusion event
HTLV-1-GSE1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr16
Cytoband
q24.1
Reference genome
GRCh37/hg19
Start
85559108/85525502 (Hg38)
End
85559108/85525502 (Hg38)
Orient
+
Location type
Intronic
Target gene
GSE1
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-769-5p ; hsa-mir-331-3p ; hsa-mir-361-3p ; hsa-mir-324-3p ; hsa-mir-759 ; hsa-mir-1913 ; hsa-mir-5586-3p ; hsa-mir-548av-3p ; hsa-mir-513a-5p ; hsa-mir-5687 ; hsa-mir-4775 ; hsa-mir-4313 ; hsa-mir-1236-5p ; hsa-mir-29c-5p ; hsa-mir-4773 ; hsa-mir-548g-3p ; hsa-mir-27b-3p ; hsa-mir-27a-3p ; hsa-mir-489-3p
Nearest miRNA
hsa-mir-12128/Upstream/219177; hsa-mir-11401/Downstream/216119;
Nearest TSS
ENST00000527434/Upstream/35689; ENST00000567093/Downstream/30465;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/7399, chr16-CpG: 272/Downstream/27830
Nearby gene
GSE1(No orient, 85921)
Upstream sequence
TCCCCAGCGTTGGGGAAATCCAGGATGCTGAGAAGGAGCGAGGTGGCCAGGCTGGCCCTAGGCTTCCTTGTTTCACAGTTTCCCTCCTACCCTGCTCATG
Downstream sequence
ATGCCCAGCCAGCCGGCAGGCTTTCCTGTGGGGGTGAATACCTCATGGTGTGGGAGCTGATCCCCCAAATGGGGGGTGTCACTGCCCACATGCCTGAGGA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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