Basic Information
VIS ID
TVIS44017963
Fusion event
HTLV-1-FBXO31 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr16
Cytoband
q24.2
Reference genome
GRCh37/hg19
Start
87416220/87382614 (Hg38)
End
87416220/87382614 (Hg38)
Orient
-
Location type
Intronic
Target gene
FBXO31
miRNAs that regulate target gene
hsa-mir-17-5p ; hsa-mir-192-5p ; hsa-mir-92b-3p ; hsa-mir-18a-3p ; hsa-mir-320a ; hsa-mir-20a-5p ; hsa-mir-106b-5p ; hsa-mir-7152-5p ; hsa-mir-3074-5p ; hsa-mir-6783-3p ; hsa-mir-1343-3p ; hsa-mir-211-5p ; hsa-mir-204-5p ; hsa-mir-3926 ; hsa-mir-3124-3p ; hsa-mir-6504-5p ; hsa-mir-3064-5p ; hsa-mir-4287 ; hsa-mir-4685-3p ; hsa-mir-8073 ; hsa-mir-221-5p ; hsa-mir-6832-3p ; hsa-mir-6768-3p ; hsa-mir-4696 ; hsa-mir-4725-5p ; hsa-mir-372-5p ; hsa-mir-371a-5p ; hsa-mir-616-5p ; hsa-mir-373-5p ; hsa-mir-371b-5p ; hsa-mir-5699-3p ; hsa-mir-4421 ; hsa-mir-339-5p ; hsa-mir-3065-5p ; hsa-mir-3613-3p ; hsa-mir-451b ; hsa-mir-10b-5p ; hsa-mir-10a-5p ; hsa-mir-3529-3p ; hsa-mir-3667-5p ; hsa-mir-519d-3p ; hsa-mir-93-5p ; hsa-mir-20b-5p
Nearest miRNA
hsa-mir-12128/Upstream/1464198; hsa-mir-11401/Downstream/451978;
Nearest TSS
ENST00000527434/Upstream/15106; ENST00000599768/Downstream/1134;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/64650, chr16-CpG: 174/Downstream/363
Nearest cancer related gene
FBXO31(TSG, No orient, 0)
Upstream sequence
TTACATCCAATATTGCTGAAGGCAAAAGTCCAGCCCGCACCGCTGTGATCCATCCGTCTCTCTACGCCCCCACCATCAGGAGCCCCCGACACTGGGCTTC
Downstream sequence
CCCTACTCCCGTAAttttttttgttgctgttgtttgagaccaagtcgcactctgtcgcctagggtggagtgcaatggcccagatgttggctcagtgcaac
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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