Basic Information
VIS ID
TVIS44017982
Fusion event
HTLV-1-COPS3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
p11.2
Reference genome
GRCh37/hg19
Start
17165716/17262402 (Hg38)
End
17165716/17262402 (Hg38)
Orient
-
Location type
Intronic
Target gene
COPS3
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-196a-5p ; hsa-mir-484 ; hsa-mir-324-5p ; hsa-mir-331-3p ; hsa-mir-328-3p ; hsa-mir-25-3p ; hsa-mir-17-5p ; hsa-let-7c-5p ; hsa-mir-218-5p
Nearest miRNA
hsa-mir-1253/Upstream/980314; hsa-mir-10226/Downstream/551078;
Nearest TSS
ENST00000595228/Upstream/1706; ENST00000478373/Downstream/8405;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/24636, chr17-CpG: 81/Downstream/18170
Nearest cancer related gene
COPS3(OG, No orient, 0)
Upstream sequence
taggctggagcgcagtgatgtaattatggctcactgtaccctcaaactccttgggttcaagcaatcttcctgcctcagcctcctgagtacctgggactat
Downstream sequence
aggagtgggccaccatgcttgactaattttaaaattttttgtagaggccaggcgcggtggcttatgcctgtaatcccagcactttgagaggccgaggtgg
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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