Basic Information
VIS ID
TVIS44017985
Fusion event
HTLV-1-TOP3A integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
p11.2
Reference genome
GRCh37/hg19
Start
18206620/18303306 (Hg38)
End
18206620/18303306 (Hg38)
Orient
+
Location type
Intronic
Target gene
TOP3A
miRNAs that regulate target gene
hsa-mir-320a ; hsa-mir-222-3p ; hsa-mir-6869-5p ; hsa-mir-4279 ; hsa-mir-1200 ; hsa-mir-6829-3p ; hsa-mir-6791-3p ; hsa-mir-3653-5p ; hsa-mir-1976 ; hsa-mir-6747-3p ; hsa-mir-6727-3p ; hsa-mir-4722-3p ; hsa-mir-544b ; hsa-mir-4324 ; hsa-mir-660-3p ; hsa-mir-5571-5p
Nearest miRNA
hsa-mir-1253/Upstream/489375; hsa-mir-10226/Downstream/37508;
Nearest TSS
ENST00000595228/Upstream/216; ENST00000406438/Downstream/3853;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/39020, chr17-CpG: 117/Downstream/11201
Upstream sequence
agtcatcgccattctccactctctattaaccagagacacaatgcactgtggaaggccgcagggacccctgcccaagaaagcctgggtattgtcaaggttt
Downstream sequence
cccccgactgagacagcctgagatatggcctcgtgggaagggaaagacttacagccccccagcccgacactcgtaaagggtcagtgctgaggaggattag
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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