Basic Information
VIS ID
TVIS44018002
Fusion event
HTLV-1-UNC45B integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
q12
Reference genome
GRCh37/hg19
Start
33498004/35170985 (Hg38)
End
33498004/35170985 (Hg38)
Orient
+
Location type
Intronic
Target gene
UNC45B
miRNAs that regulate target gene
hsa-mir-324-3p ; hsa-mir-4668-5p ; hsa-mir-519e-5p ; hsa-mir-515-5p ; hsa-mir-6895-3p ; hsa-mir-6845-3p ; hsa-mir-5695 ; hsa-mir-3184-3p ; hsa-mir-519d-5p
Nearest miRNA
hsa-mir-1180/Upstream/2820783; hsa-mir-10226/Downstream/1862760;
Nearest TSS
ENST00000595228/Upstream/3973; ENST00000592325/Downstream/23538;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/28586, chr17-CpG: 90/Downstream/71137
Upstream sequence
GCCCTCCCTCCCAGGCCCCCCCAGACTCCTTTCCTCATCTGCTGGGCCAACTCCCTGGCCCTTTTCTACCAGTAAATGGAGGAAGCATGGGAGAGATTTT
Downstream sequence
CACCAGGACCGGAAAATGTCCAGCTCCCACCCCATCTCCAGTTGGATGGGAAAGTGTTAGACTGGGCTTGTGGAAGAGGCGCAAAGCGAGGATCTTTGTG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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