Basic Information
VIS ID
TVIS44018004
Fusion event
HTLV-1-AATF integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
q12
Reference genome
GRCh37/hg19
Start
35366556/37009257 (Hg38)
End
35366556/37009257 (Hg38)
Orient
+
Location type
Intronic
Target gene
AATF
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-151a-3p ; hsa-mir-149-5p ; hsa-let-7b-5p ; hsa-mir-4530 ; hsa-mir-1226-3p ; hsa-mir-634 ; hsa-mir-525-3p ; hsa-mir-524-3p
Nearest miRNA
hsa-mir-1180/Upstream/4659055; hsa-mir-10226/Downstream/24488;
Nearest TSS
ENST00000595228/Upstream/18482; ENST00000616062/Downstream/9694;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/59800, chr17-CpG: 76/Downstream/349596
Upstream sequence
tttcactcttgttgcccaggctggagtgcagtggcgcgatctcggctcactgcaacctccacctcctgggttcaagtgattcttctgcctcaggctcccg
Downstream sequence
agtagctgggattacaggcatctgccaccatgcccggctaattttttttttttttttttgtatttttagtaaagatggggtttcaccatgttggccaggc
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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