Basic Information
VIS ID
TVIS44018005
Fusion event
HTLV-1-MLLT6 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
q12
Reference genome
GRCh37/hg19
Start
36864257/38708004 (Hg38)
End
36864257/38708004 (Hg38)
Orient
-
Location type
Intronic
Target gene
MLLT6
miRNAs that regulate target gene
hsa-mir-103a-3p ; hsa-mir-93-5p ; hsa-mir-16-5p ; hsa-mir-1303 ; hsa-mir-877-3p ; hsa-mir-23b-3p ; hsa-mir-4477a ; hsa-mir-15a-5p ; hsa-mir-15b-5p ; hsa-mir-195-5p ; hsa-mir-377-3p ; hsa-mir-342-3p ; hsa-mir-603 ; hsa-mir-8485 ; hsa-mir-4643 ; hsa-mir-129-5p ; hsa-mir-3680-3p ; hsa-mir-557 ; hsa-mir-507 ; hsa-mir-450b-5p ; hsa-mir-527 ; hsa-mir-518a-5p ; hsa-mir-548aw ; hsa-mir-1468-3p ; hsa-mir-548x-5p ; hsa-mir-548g-5p ; hsa-mir-548f-5p ; hsa-mir-548aj-5p ; hsa-mir-543 ; hsa-mir-3166 ; hsa-mir-4329 ; hsa-mir-4692 ; hsa-mir-4514 ; hsa-mir-1324 ; hsa-mir-6511a-5p ; hsa-mir-1910-3p ; hsa-mir-483-5p ; hsa-mir-4524b-3p
Nearest miRNA
hsa-mir-1180/Upstream/5673; hsa-mir-10226/Downstream/11687;
Nearest TSS
ENST00000595228/Upstream/1053; ENST00000618652/Downstream/1076;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/1846, chr17-CpG: 83/Downstream/21851
Upstream sequence
TCCCTCCCATCTATGGGTTCCTCCAACGCTCTCTTCATCCGGTGTAATTTGATTCTGTCCAACGAGCACTGAAAGGGAACTTGGGAGGTGGGTAGGTACC
Downstream sequence
TACCAGTGAACCACCCTTCTGTTGACAGACACACTCATGCTCTGGCACTCAGGTGAAATAGTAGGCTCCCCTGCAGTAGTTCTGCCAGAGGGTAGACCTT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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