Basic Information
VIS ID
TVIS44018016
Fusion event
HTLV-1-ATP5MC1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
q21.32
Reference genome
GRCh37/hg19
Start
46971850/48894488 (Hg38)
End
46971850/48894488 (Hg38)
Orient
-
Location type
Intronic
Target gene
ATP5MC1
miRNAs that regulate target gene
hsa-mir-7151-3p ; hsa-mir-5095 ; hsa-mir-3116 ; hsa-mir-1254 ; hsa-mir-149-5p ; hsa-mir-488-5p ; hsa-mir-4438 ; hsa-mir-1303 ; hsa-mir-5096 ; hsa-mir-3157-5p ; hsa-mir-197-3p ; hsa-mir-411-5p ; hsa-mir-6832-5p ; hsa-mir-193b-5p ; hsa-mir-4691-3p ; hsa-mir-6858-3p ; hsa-mir-483-5p ; hsa-mir-7850-5p ; hsa-mir-4309 ; hsa-mir-3198 ; hsa-mir-620 ; hsa-mir-1270 ; hsa-mir-4531 ; hsa-mir-6794-3p ; hsa-mir-4294 ; hsa-mir-1289 ; hsa-mir-4683 ; hsa-mir-4639-3p ; hsa-mir-3664-5p
Nearest miRNA
hsa-mir-10226/Upstream/170013; hsa-mir-1250/Downstream/393858;
Nearest TSS
ENST00000595228/Upstream/321; ENST00000515060/Downstream/373;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/1725, chr17-CpG: 104/Downstream/13738
Upstream sequence
GGGTCTAATCAGGCCTGTGTCTGCCTCCTTCTTGAATAGCCCAGTGAATTCATCTAAACAGGTAAGGGAGGAATAGCTCTCTTAGGAATGTTCCCAAGGC
Downstream sequence
CCAGGATggtggctcacacctgtaatcccagctctttgagaggctgaggcgagaggatcacttgagcccagttgttcaagaccagcctgggcaacacagt
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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