Basic Information
VIS ID
TVIS44018035
Fusion event
HTLV-1-APPBP2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
q23.2
Reference genome
GRCh37/hg19
Start
58594771/60517410 (Hg38)
End
58594771/60517410 (Hg38)
Orient
+
Location type
Intronic
Target gene
APPBP2
miRNAs that regulate target gene
hsa-mir-148a-3p ; hsa-mir-4452 ; hsa-mir-670-5p ; hsa-mir-513a-5p ; hsa-mir-2052 ; hsa-mir-6128 ; hsa-mir-6791-5p ; hsa-mir-4308 ; hsa-mir-4292 ; hsa-mir-3681-3p ; hsa-mir-3938 ; hsa-mir-216a-3p ; hsa-mir-27b-3p ; hsa-mir-27a-3p ; hsa-mir-128-3p ; hsa-mir-144-3p ; hsa-mir-4497
Nearest miRNA
hsa-mir-10226/Upstream/474305; hsa-mir-1250/Downstream/2426805;
Nearest TSS
ENST00000595228/Upstream/52249; ENST00000559739/Downstream/8528;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/95439, chr17-CpG: 64/Downstream/8251
Upstream sequence
gtgtacaatgagtcctttgtcagatacaggtgctgcaaatatcttctcccactctgtggcttgactcttcacttgcttaatgatatcttttgatgagatg
Downstream sequence
ttcttgatcttaatatagcaccaatttatcacacttcctttatatttaaccactttgagatccaaattaatctttgctgacataaaatttttttctaaaa
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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