Basic Information
VIS ID
TVIS44018038
Fusion event
HTLV-1-BRIP1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
q23.2
Reference genome
GRCh37/hg19
Start
59820697/61743336 (Hg38)
End
59820697/61743336 (Hg38)
Orient
+
Location type
Intronic
Target gene
BRIP1
miRNAs that regulate target gene
hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-378a-5p ; hsa-mir-182-5p ; hsa-mir-34b-3p ; hsa-mir-3614-5p ; hsa-mir-3689d ; hsa-mir-3929 ; hsa-mir-4254 ; hsa-mir-4419b ; hsa-mir-4478 ; hsa-mir-455-3p ; hsa-mir-4649-3p ; hsa-mir-4722-5p ; hsa-mir-4768-3p ; hsa-mir-490-3p ; hsa-mir-493-3p ; hsa-mir-510-5p ; hsa-mir-512-5p ; hsa-mir-619-3p ; hsa-mir-6499-3p ; hsa-mir-6500-3p ; hsa-mir-6516-5p ; hsa-mir-6808-5p ; hsa-mir-6851-5p ; hsa-mir-6893-5p ; hsa-mir-7160-5p ; hsa-mir-7854-3p ; hsa-mir-940
Nearest miRNA
hsa-mir-10226/Upstream/1700231; hsa-mir-1250/Downstream/1200879;
Nearest TSS
ENST00000595228/Upstream/152134; ENST00000635817/Downstream/33144;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/280863, chr17-CpG: 21/Downstream/120128
Upstream sequence
TTAAAATAATCAAAATAAAACACTATTATGAGATAAAGTTTTAAAAGTTCAATGTCTTTAAGTAAATAAGGGGAACAAAATTACATTTATATGCAAAAGG
Downstream sequence
GTAGCAAACCAATTTACAAACTCTGCATCTTCCAGATAACTTATACAGTAAAAACATGTCAGAATAGCAACTTGCATATGAACTGTGTGATTATAAACAG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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