Basic Information
VIS ID
TVIS44018059
Fusion event
HTLV-1-FXR2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
p13.1
Reference genome
GRCh37/hg19
Start
7507362/7604044 (Hg38)
End
7507362/7604044 (Hg38)
Orient
+
Location type
Exonic
Target gene
FXR2
miRNAs that regulate target gene
hsa-mir-30a-5p ; hsa-mir-324-3p ; hsa-mir-196a-5p ; hsa-mir-17-5p ; hsa-let-7b-5p ; hsa-mir-10b-5p ; hsa-mir-376c-3p ; hsa-mir-539-5p ; hsa-mir-4260 ; hsa-mir-6803-5p ; hsa-mir-6751-5p ; hsa-mir-1227-5p ; hsa-mir-4531 ; hsa-mir-124-5p ; hsa-mir-6880-5p ; hsa-mir-609 ; hsa-mir-6747-5p ; hsa-mir-7110-5p ; hsa-mir-6842-5p ; hsa-mir-6752-5p ; hsa-mir-6835-5p ; hsa-mir-486-3p ; hsa-mir-5703 ; hsa-mir-4516 ; hsa-mir-5186 ; hsa-mir-4434 ; hsa-mir-4756-3p ; hsa-mir-3919 ; hsa-mir-552-3p
Nearest miRNA
hsa-mir-1253/Upstream/380665; hsa-mir-10226/Downstream/484012;
Nearest TSS
ENST00000595228/Upstream/2608; ENST00000624152/Downstream/22;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/14417, chr17-CpG: 78/Downstream/10328
Upstream sequence
AGCAACTTTCTATGAATAACATATTTGTTTCAGTAGTTCTCCAAAGGCATTCCCAGTCACTCACATCTCCCTTCATCATCCGCACCCGGGCCAGCCACCA
Downstream sequence
GCCACAAGGTTCCTGTTCATTGGCTCGAGAATAAACCTAAAGAAAAGTAGAGAATCAAAGAGATATTGAAGACCACCCAAAAGCATCAAGAAAGGGATGA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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