Basic Information
VIS ID
TVIS44018061
Fusion event
HTLV-1-ATP1B2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
p13.1
Reference genome
GRCh37/hg19
Start
7557796/7654478 (Hg38)
End
7557796/7654478 (Hg38)
Orient
+
Location type
Intronic
Target gene
ATP1B2
miRNAs that regulate target gene
hsa-mir-335-5p
Nearest miRNA
hsa-mir-1253/Upstream/431099; hsa-mir-10226/Downstream/433578;
Nearest TSS
ENST00000595228/Upstream/369; ENST00000463804/Downstream/19109;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/2458, chr17-CpG: 23/Downstream/31494
Upstream sequence
GAGAGAAAAAGAGAGGTGGGACTCTTGGAGGCTAAGCTCTGCAGTTAGAAGGCTGGATGCCttttgttttttttttagacagggtcttgctatgttgccc
Downstream sequence
aggctggccttgaactcctggaattaagctatcctcccgcctcaacctccctagtagttgggactacagTCCCCGGCTTAGCTTGGTCTGGATGCCCATC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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