Basic Information
VIS ID
TVIS44018068
Fusion event
HTLV-1-FASN integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
q25.3
Reference genome
GRCh37/hg19
Start
80043990/82086114 (Hg38)
End
80043990/82086114 (Hg38)
Orient
-
Location type
Intronic
Target gene
FASN
miRNAs that regulate target gene
hsa-mir-2110 ; hsa-mir-1268a ; hsa-mir-1303 ; hsa-mir-942-5p ; hsa-mir-877-3p ; hsa-mir-744-5p ; hsa-mir-130b-5p ; hsa-mir-615-3p ; hsa-mir-92b-3p ; hsa-mir-193b-3p ; hsa-mir-484 ; hsa-mir-423-3p ; hsa-mir-324-3p ; hsa-mir-331-3p ; hsa-mir-326 ; hsa-mir-186-5p ; hsa-mir-27b-3p ; hsa-mir-222-3p ; hsa-mir-10b-5p ; hsa-mir-10a-5p ; hsa-mir-197-3p ; hsa-mir-93-5p ; hsa-mir-92a-3p ; hsa-mir-26a-5p ; hsa-mir-17-5p ; hsa-mir-15a-5p ; hsa-mir-424-5p ; hsa-mir-195-5p ; hsa-mir-1-3p ; hsa-mir-15b-3p ; hsa-mir-4668-3p ; hsa-mir-15b-5p ; hsa-mir-16-5p ; hsa-mir-6838-5p ; hsa-mir-497-5p ; hsa-mir-4774-3p ; hsa-mir-4314 ; hsa-mir-6740-3p ; hsa-mir-3182 ; hsa-mir-6776-5p ; hsa-mir-6861-5p ; hsa-mir-1264 ; hsa-mir-6771-3p ; hsa-mir-486-3p ; hsa-mir-532-5p ; hsa-mir-30c-5p
Nearest miRNA
hsa-mir-10226/Upstream/392245; hsa-mir-4525/Downstream/150554;
Nearest TSS
ENST00000595228/Upstream/454; ENST00000579979/Downstream/9262;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/701, chr17-CpG: 23/Downstream/2064
Nearest cancer related gene
FASN(OG, No orient, 0)
Upstream sequence
ATGCCACTGGTCTTGTCCCTGGGGTCCTGCCTAGGCTGCACCTCTTGGAGCCCACGGGCGGACCCTCCACGGTGGCTGTGTGGACCGCACAGGACACGTG
Downstream sequence
CACAGAACCACACAGGGAACTGGCCGGCCCCACCCACCGCCCAGGGCCCGCCCCGTGTCTGTGCTGTCTCCTGCAACTGATGTCAGGGTGGGTCCTACCA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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