Basic Information
VIS ID
TVIS44018087
Fusion event
HTLV-1-MIB1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr18
Cytoband
q11.2
Reference genome
GRCh37/hg19
Start
19334475/21754514 (Hg38)
End
19334475/21754514 (Hg38)
Orient
-
Location type
Intronic
Target gene
MIB1
miRNAs that regulate target gene
hsa-mir-210-3p ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-103a-3p ; hsa-mir-21-5p ; hsa-mir-16-5p ; hsa-mir-193b-3p ; hsa-let-7b-5p ; hsa-let-7a-5p ; hsa-mir-541-5p ; hsa-mir-374a-5p ; hsa-mir-6885-3p ; hsa-mir-7151-3p ; hsa-mir-5095 ; hsa-mir-3619-3p ; hsa-mir-3140-3p ; hsa-mir-4700-3p ; hsa-mir-335-3p ; hsa-mir-889-3p ; hsa-mir-5579-5p ; hsa-mir-590-3p ; hsa-mir-5583-3p ; hsa-mir-4517 ; hsa-mir-4753-3p ; hsa-mir-1236-3p ; hsa-mir-6515-3p ; hsa-mir-4636 ; hsa-mir-30d-5p ; hsa-mir-30e-5p ; hsa-mir-30c-5p ; hsa-mir-30b-5p ; hsa-mir-30a-5p ; hsa-mir-195-5p ; hsa-mir-15b-5p ; hsa-mir-15a-5p
Nearest miRNA
hsa-mir-3156-2/Upstream/70925; hsa-mir-1-2/Downstream/71184;
Nearest TSS
ENST00000575820/Upstream/13194; ENST00000577749/Downstream/43570;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/12536, chr18-CpG: 20/Downstream/142377
Upstream sequence
gtcaccgtgtccagcctccccacactgcctatgctgcccacctatttagtcacttagtagctgcctcttatcagatcaactgtcatggtattgtggggct
Downstream sequence
cgtgttcacataacccttacttgactttataatggccccaaagctgaagagcggtgatgttggcaattcagacaggtcaaagagaagccatcaagtgcat
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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