Basic Information
VIS ID
TVIS44018105
Fusion event
HTLV-1-PIAS2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr18
Cytoband
q21.1
Reference genome
GRCh37/hg19
Start
44469874/46889911 (Hg38)
End
44469874/46889911 (Hg38)
Orient
+
Location type
Intronic
Target gene
PIAS2
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-3658 ; hsa-mir-3653-3p ; hsa-mir-4720-3p ; hsa-mir-6507-5p ; hsa-mir-6126 ; hsa-mir-3140-3p ; hsa-mir-4493 ; hsa-mir-605-3p ; hsa-mir-497-3p ; hsa-mir-498 ; hsa-mir-4279 ; hsa-mir-4713-5p ; hsa-mir-23b-5p ; hsa-mir-23a-5p ; hsa-mir-1976 ; hsa-mir-3653-5p ; hsa-mir-2116-3p ; hsa-mir-532-3p ; hsa-mir-150-5p ; hsa-mir-6742-3p ; hsa-mir-6747-3p ; hsa-mir-6727-3p ; hsa-mir-4722-3p ; hsa-mir-1281 ; hsa-mir-1343-3p ; hsa-mir-4485-5p ; hsa-mir-660-3p ; hsa-mir-6783-3p ; hsa-mir-6791-3p ; hsa-mir-6829-3p ; hsa-mir-6852-5p ; hsa-mir-939-3p ; hsa-mir-129-5p ; hsa-mir-1303 ; hsa-mir-1304-3p ; hsa-mir-133a-3p ; hsa-mir-133b ; hsa-mir-215-3p ; hsa-mir-3664-5p ; hsa-mir-4639-3p ; hsa-mir-5007-5p ; hsa-mir-6758-5p ; hsa-mir-6773-3p ; hsa-mir-6794-3p ; hsa-mir-6843-3p ; hsa-mir-6848-3p ; hsa-mir-6856-5p ; hsa-mir-6879-3p
Nearest miRNA
hsa-mir-1-2/Upstream/1919745; hsa-mir-122/Downstream/490585;
Nearest TSS
ENST00000575820/Upstream/25679; ENST00000585383/Downstream/16319;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/131774, chr18-CpG: 126/Downstream/27036
Upstream sequence
gggagcaacccaagtgtccaatggataagcaaaatgtggtatCCTATAACACagaaatatagaagtaaaaccagaagaaacagctaaaataattaaggtt
Downstream sequence
gttgcctcttgaaagtgagATTGAGGGATGAGTAGTGGAGTGAGCAAAAGATTACTATTTTTCTTTAAAAATGTATACTATTGtattatttagcctttaa
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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