Basic Information
VIS ID
TVIS44018120
Fusion event
HTLV-1-WDR7 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr18
Cytoband
q21.31
Reference genome
GRCh37/hg19
Start
54573227/56905996 (Hg38)
End
54573227/56905996 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA18B
Target gene
WDR7
miRNAs that regulate target gene
hsa-mir-21-5p ; hsa-mir-18a-3p
Nearest miRNA
hsa-mir-1-2/Upstream/1426698; hsa-mir-122/Downstream/1545078;
Nearest TSS
ENST00000575820/Upstream/15163; ENST00000585669/Downstream/29848;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/254442, chr18-CpG: 24/Downstream/215732
Upstream sequence
tagggaattaacttattttgaaaattagtacattttatacacatgtacctcagcataatcaaatggttgatgaaaggaaattcttctttataacaatatt
Downstream sequence
gtagccaataaatgaagaaggaatgatggaatataatcattttgccacccctaatgtattaatggacctgggcaatcactcctaatatcaccgtaagaga
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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