Basic Information
VIS ID
TVIS44018127
Fusion event
HTLV-1-LINC00305 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr18
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
61749842/64082608 (Hg38)
End
61749842/64082608 (Hg38)
Orient
+
Location type
ncRNA_intronic
Target gene
LINC00305
miRNAs that regulate target gene
hsa-mir-335-5p
Nearest miRNA
hsa-mir-1-2/Upstream/5631450; hsa-mir-5011/Downstream/2998976;
Nearest TSS
ENST00000575820/Upstream/97432; ENST00000417298/Downstream/16002;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/79587, chr18-CpG: 88/Downstream/1667992
Upstream sequence
gtctagataaataggctctatctgggcagtgggcaaggagaatcctttgggcagctacaGTGGCAGAGACAGAAATGGATTGCACAAAGCTTAACCAGGA
Downstream sequence
ATTCACATCACTGGCTTGCTGACAGTGTGAATTCTGTATCTATCCTCAGCCTAGTCCTCTTTCCAGTCTTGTTCCCTCTTTCACCTGCACACTAACTATA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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