Basic Information
VIS ID
TVIS44018136
Fusion event
HTLV-1-NETO1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr18
Cytoband
q22.3
Reference genome
GRCh37/hg19
Start
70486662/72819427 (Hg38)
End
70486662/72819427 (Hg38)
Orient
-
Location type
Intronic
Target gene
NETO1
miRNAs that regulate target gene
hsa-mir-5692a ; hsa-mir-497-3p ; hsa-mir-6826-3p ; hsa-mir-3938
Nearest miRNA
hsa-mir-1-2/Upstream/5737741; hsa-mir-548av/Downstream/33894;
Nearest TSS
ENST00000575820/Upstream/70389; ENST00000578967/Downstream/46272;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/274872, chr18-CpG: 275/Downstream/47303
Upstream sequence
AACCTTTACATATATCTGCCTTTCCTTGTGTTACAAAAAAGGATGGGCTTCTAAAGAGCTCTATAATTGCTGAAATTCTGAGAACTGATTAGTATTTTAT
Downstream sequence
AATTAGATAATTCTATGATTTCAAAAATATTTGACGTTGATACTGGATTTATTTCAAAATGAGATAGCTTCATAACATTCCTAAGCTTTGCCCTAGTCAT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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