Basic Information
VIS ID
TVIS44018143
Fusion event
HTLV-1-PTPRM integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr18
Cytoband
p11.23
Reference genome
GRCh37/hg19
Start
7809122/7809124 (Hg38)
End
7809122/7809124 (Hg38)
Orient
+
Location type
Intronic
Target gene
PTPRM
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-205-5p ; hsa-mir-3680-3p ; hsa-mir-557 ; hsa-mir-507 ; hsa-mir-450b-5p ; hsa-mir-580-3p ; hsa-mir-4753-3p ; hsa-mir-452-3p ; hsa-mir-6770-5p ; hsa-mir-1253 ; hsa-mir-1279 ; hsa-mir-130b-5p ; hsa-mir-4461 ; hsa-mir-1264
Nearest miRNA
hsa-mir-3976/Upstream/1434699; hsa-mir-1-2/Downstream/2950460;
Nearest TSS
ENST00000575820/Upstream/34984; ENST00000578916/Downstream/137746;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/240292, chr18-CpG: 38/Downstream/558151
Upstream sequence
ttccccatgaatttaattctcagcagtcattacccacatgtgacagttaaggaccctgagacttgaggaggctaagGATTCAATCTCAGTCCCTGGAGCT
Downstream sequence
GGTGGGTGTTCCCATGAGGCTTCTAGCCTGGCTTTCTCTCTCATCAGCCCCCTTCATCACCTGGTGTTTTCCAGGATGCCGGTAGGAGGCGGCAGGCAAG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
Curate