Basic Information
VIS ID
TVIS44018146
Fusion event
HTLV-1-CTDP1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr18
Cytoband
q23
Reference genome
GRCh37/hg19
Start
77461106/79701106 (Hg38)
End
77461106/79701106 (Hg38)
Orient
-
Location type
Intronic
Target gene
CTDP1
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-193b-3p ; hsa-let-7d-5p ; hsa-let-7a-5p ; hsa-mir-3191-3p ; hsa-mir-512-3p ; hsa-mir-6131 ; hsa-mir-6784-5p ; hsa-mir-7152-3p
Nearest miRNA
hsa-mir-1-2/Upstream/6847724;
Nearest TSS
ENST00000575820/Upstream/19647; ENST00000585951/Downstream/2545;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/6489, chr18-CpG: 43/Downstream/3218
Upstream sequence
ccattctaagcccgctcttgagacctgttactcagaaagagagattcttctaagaaatattcctgctcattgaccatgcacctggtcacccaagagctct
Downstream sequence
gatggagacgtacaggagaggaatgttgttttcatgctgctgacaccacatccaccctgcagcccagggctcaagaaatgatttccagcttcaagtctta
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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