Basic Information
VIS ID
TVIS44018150
Fusion event
HTLV-1-RALBP1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr18
Cytoband
p11.22
Reference genome
GRCh37/hg19
Start
9534461/9534463 (Hg38)
End
9534461/9534463 (Hg38)
Orient
+
Location type
Intronic
Target gene
RALBP1
miRNAs that regulate target gene
hsa-mir-1914-5p ; hsa-mir-615-3p ; hsa-mir-125a-5p ; hsa-mir-10b-5p ; hsa-mir-10a-5p ; hsa-mir-185-5p ; hsa-mir-298 ; hsa-mir-3150b-3p ; hsa-mir-3158-5p ; hsa-mir-4306 ; hsa-mir-4418 ; hsa-mir-4428 ; hsa-mir-4481 ; hsa-mir-4640-5p ; hsa-mir-4644 ; hsa-mir-4693-3p ; hsa-mir-4726-5p ; hsa-mir-4745-5p ; hsa-mir-4784 ; hsa-mir-509-3-5p ; hsa-mir-509-5p ; hsa-mir-5192 ; hsa-mir-6508-3p ; hsa-mir-6758-5p ; hsa-mir-6856-5p
Nearest miRNA
hsa-mir-3976/Upstream/3160038; hsa-mir-1-2/Downstream/1225121;
Nearest TSS
ENST00000575820/Upstream/58328; ENST00000584109/Downstream/15837;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/55541, chr18-CpG: 173/Downstream/79274
Upstream sequence
CCCAAATAAAATATTGTGTCCAGATATTTTGCCTAAGGATTGAGTGAGAGAAGATACCCTCTTCACAGAAAGGAATCTAAGGATAGAGGGACAGCTCTGC
Downstream sequence
ATCCCTCATTTGGGTTCGCTCAGTGGCTGGTGCGAACCAGAACTACACCCTGCATAGAAAAGCAGAATTCCACACACAGCCACCCTGCACAGAGTCCTCT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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