Basic Information
VIS ID
TVIS44018152
Fusion event
HTLV-1-ZNF627 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr19
Cytoband
p13.2
Reference genome
GRCh37/hg19
Start
11689899/11579084 (Hg38)
End
11689899/11579084 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA19B
Target gene
ZNF627
miRNAs that regulate target gene
hsa-mir-27b-3p ; hsa-mir-27a-3p
Nearest miRNA
hsa-mir-1181/Upstream/83462; hsa-let-7e/Downstream/1124517;
Nearest TSS
ENST00000633603/Upstream/76; ENST00000587939/Downstream/18336;
Nearest CpG islands
chr19-CpG: 49/Target, None/Upstream, None/Downstream
Nearby gene
ACP5(-98) ;
Upstream sequence
cggggagggcgggcgcctcggcctccccgccccggAACCCTGCACCGCCCAGAGCCGCCACGCCTCCCGGCTGTAGGCTCCGCATCTGTAAAATGGGCCG
Downstream sequence
ATGAACCCCAAGGGTCGGCTCAGACCCACGGACTGCAGCTGCAGCTGGGCTAGAAGGGGTGGCCAGGGGAGCCGATTTCATCCTTTTCCTTCCTCCACGC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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