Basic Information
VIS ID
TVIS44018154
Fusion event
HTLV-1-MAST1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr19
Cytoband
p13.13
Reference genome
GRCh37/hg19
Start
12948396/12837582 (Hg38)
End
12948396/12837582 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA19B
Target gene
MAST1
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-148b-3p
Nearest miRNA
hsa-mir-10395/Upstream/50390; hsa-let-7e/Downstream/14678;
Nearest TSS
ENST00000633603/Upstream/2154; ENST00000592713/Downstream/891;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/3097, chr19-CpG: 30/Downstream/1010
Nearby gene
MAST1(+863) ;
Upstream sequence
aggcctttgcccttgcagttccctccacctggaatgctctctccacagatcctcccatggctggctcttatctttcagcaaccagcttaaaagtcacctc
Downstream sequence
cacagagcagccctgtctgacaatgtgtctccatcctagccattgtccatcacatcaccctgtttaatttattcataagactaattattgtctaaaatga
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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